Bruch's membrane

The blood-retina barrier that separates the retina from the rest of the body, that is often broken in individuals with wet AMD.

The Bruch's membrane is the blood-retina barrier that separates the RPE cells of the retina from the choroid. This membrane is structurally similar to the blood-brain barrier, because the retina is an extension of the brain. A rupture of this barrier can cause diseases, like AMD, where the choroid blood vessels grow abnormally into the retina and cause damage, ultimately affecting vision.