Background
Gray font color on white background Black font color on white background White font color on black background White font color on dark blue background
Font Size

Foundation News » Retinitis Pigmentosa
PDF Print E-mail Bookmark Share This Page

Researchers Find Further Evidence That Bile Acid Slows Vision Loss in Mice

Image of girl looking through microscopeJanuary 19, 2012 – A recent Foundation-funded study shows that a synthetically derived bile acid slowed the rate of vision loss in mice with specific types of retinal degenerative diseases. According to researchers at the University of Iowa, tauroursodeoxycholic acid, or TUDCA, performed well in mouse models of autosomal recessive retinitis pigmentosa (RP) and Bardet-Biedl syndrome type 1 (BBS1), which causes a variety of physical and developmental symptoms, including obesity and RP. The results are consistent with those from earlier studies, also funded by the Foundation.

The Iowa team, which reported its study in the online issue of the journal Investigative Ophthalmology & Visual Science, believes that TUDCA holds the greatest potential for treating slower and later-onset retinal disease. It also thinks TUDCA may help control obesity in BBS1 patients, though the team cautions that further study is needed to understand TUDCA’s effect on weight loss.

The Foundation is currently funding a lab study at Oregon Health & Science University to determine the optimal oral dose of TUDCA for treating humans with retinal degenerations such as RP. If results of that study are favorable, the Foundation hopes to launch a clinical trial in early 2013.

“TUDCA looks very promising at this point, but we need to determine how much of the drug must be taken orally to reach the retina,” says Dr. Patricia Zilliox, the Foundation’s chief drug development officer. “We need to ensure we can get an effective dose to the back of the eye without causing unwanted side effects before we move it into a human trial.”

The natural form of the bile, most commonly found in bears, has been used in traditional Chinese medicine for thousands of years to treat a variety of ailments and conditions. There is even a 3,000-year-old scroll that mentions it as being a cure for blindness. TUDCA, the synthetic form, is currently used in Europe to treat gastrointestinal disorders. Recently, scientists have evaluated the drug for conditions such as diabetes, obesity and neurodegenerative disorders, including Huntington and Alzheimer diseases.

In retinal disease, TUDCA appears to work by blocking the death of photoreceptors, the rod and cones cells that provide vision. While programmed cell death, a process known as apoptosis, is a normal biological activity that helps the body rid itself of unneeded cells, disorders such as RP cause excess apoptosis.

The Iowa research team notes that TUDCA might be beneficial to patients with retinal degenerative diseases who are awaiting a future gene therapy or for whom the genetic cause of disease has not been identified.

Dr. Arlene Drack, lead investigator of the study, is the recipient of a Marjorie Carr Adams Women’s Career Development Award from the Foundation. 

 

Back to top

US Images

Chapters

Select a state from the dropdown below to view local chapters.


Free Information

Register here to receive free information about your eye condition and research efforts to find treatments and cures.

VISIONS 2014 banner
2013 Annual Report banner
VisionWalk banner
Events Calendar
Während wir uns immer Deutsch Porno Porno Gratis Porno Porno Of Germany und Deutschen