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Gene Therapy Revives Cones Long After They Stop Working

October 4, 2011 - If you could do one thing for a person losing their vision to a retinal disease, saving their cones would be near the top of the list. That’s because cones are the retinal cells that allow people to see color and fine detail, enabling them to drive, read and see the faces of loved ones.

A Foundation-funded research collaboration from the Institut de la Vision in Paris and the Friedrich Miescher Institute in Basel, Switzerland, is developing a gene therapy that revives degenerating cones, enabling them to regain their ability to respond to light and provide vision. The treatment also improves the health of cones and extends their lifespan significantly. A key benefit of the approach is that it may help people affected by a range of conditions, because it works independently of the underlying disease-causing genetic defect. The collaboration’s goal is to move the gene therapy into a clinical trial within three years.

In 2010, the investigative team showed that their treatment was effective and well sustained in both slow and fast models of retinal degeneration in mice. The scientists performed visual behavior and retinal sensitivity tests to demonstrate that the mice regained functional vision after treatment.

The therapy involves delivery of a gene to cones that leads to the production of a microbial protein called halorhodopsin, Üstüme transparanımsı bi gömlek giydim ve annem bi şey demesin diye üstüme de hırka aldım sikiş izle O da annemler 2 aylık tatile gittiler , hadi biz başlayalım dedi. üzerime doğra yaklaştı arkam da da yatak varmış porno Mert bazen arkama geçip balon alma niyetiyle bana sürtünüyodu sex hikayeleri Burdan dışarı çıkmak istiyosan anahtarı olduğu yerden al. Gittim elimi attım kilodunun içine.Anahtar yoktu.Ve türk porno bugün evire çevire sikemezsem bu resimleri hem Fayıma gösteririm elime durmadan onun penisi geliyodu sikiş Eteğim yatınca açılmıştı zaten porno izle Ağzımı bez barçasıyla çok sıkı bağladı rokettube Penisine tükürdü ve benim amcığıma parmağını sokup sokup çıkardı. Kızlığımı bozdu sonra tükürdü erotik hikayeler İçine boşalayımmı ha sikiş izle Ben başımı olumsuz şekilde yalvarır gibi salladım porno Ama içime boşaldı hayvan. öpüşürken kulağına senin birazdan götünü parçalayacağım dedim ataköy escort Hayır hiç yapmadım vermem dedi bayan escort amını yalamaya başladım anal escort birden bire hızlanmaya başlayarak kadını oracıkta boşalana kadar siktim. which restores light sensitivity. In retinal degenerative conditions, such as retinitis pigmentosa, cones remain present for a long time after they stop working.

To move the treatment into the clinic, the researchers will test the treatment in large animal models and adapt it for use in humans. The team is already putting together a patient screening protocol — which includes imaging, visual field testing and evaluation of retinal sensitivity — to identify people who may be eligible for the forthcoming clinical trial.

The Foundation is providing nearly $1.5 million in funding over three years for the project.

 

 

 

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