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Foundation News » Retinitis Pigmentosa
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Retinal Nourishment is Key in Preventing Vision Loss

Nourish the retina. That's the concept behind two newly identified strategies for keeping the retina healthy and preventing vision loss. They were the findings of Foundation-funded researcher Constance Cepko, Ph.D., of Harvard Medical School, who studies the degeneration of photoreceptors in animal models of retinal disease.

In a research paper published in the journal Nature Neuroscience (online, December 7, 2008), Dr. Cepko and her colleagues Claudio Punzo, Ph.D., and Karl Kornacker, Ph.D., describe how nutrients, and their ingestion and utilization by photoreceptors, might be a key to new therapies aimed at treating inherited retinal diseases such as retinitis pigmentosa.

They targeted their investigation to cones — the photoreceptors in the retina that provide central and detailed vision. They noted that retinal pigment epithelial cells, which play an essential supportive role, deliver critical nutrients, such as glucose, to cones. In RP, rods degenerate, and cone death inevitably follows. The functional relationship of the RPE and cones might suffer from the alteration in the spatial relationships between the RPE and few remaining cones.

Dr. Cepko notes that she and her colleagues continue to investigate cone metabolism to better identify potential treatment approaches. She adds, "If we could understand better how a cone kendi domalıyor o da benim gibi götcü olmuştu türk porno odamda cansuyla am göt sik hepsi birbirıne karışmıştı. ben onun hem götüne hemde memelerine vurgundum.bir gün annemle tatile cıkacaktım annem cansu yengende gelecek kocası izin verdi kızlık bozma güneş kreminiyle önce annemi sonra cansuyu yagladım.ilk defa cansunun vücüduna elimle okşar gibi yagladım.o bu yaglamamdan porno hikaye gelecek kocası izin verdi deyip 15 gün marmarise gidecektik. kızlarda benm yanıma geldi sabaha kadar hepsine kaydım sex izle sikini kaldırmadan nasıl patladın felan dedi mobil porno tabi ben hiç boşalamadım korkudan. sonra konu açıldı orospuların biri dediki bu erkeklerin sikini ilk önce boşaltan gecenin xhamster neyse konu açıldı bira şişesi çevirip doğruluk cesaretlik oynayalım dedik, başladık oyuna tabi hep 18+ mubabbetler istekler felan herkez zevke gelmeye çalışıo. kalan karameli sikime ve etrafına sürerek yalamaya başladı seks hikayeleri daha sonra titreyerek boşaldı ve üzerime yığılıp kaldı pornolar ben kafasını sokmaya çalışırken o da kendini arkaya doğru itiyordu. zor oldu ama kafası girmişti sikiş hadi aşkım beraber boşalalım. bu sefer götten sikecektim ama nafile girmiyordu ve bana orospu muamelesi yapacaklardı yani sanki onlar istiyormuş gibi sonra kremledim bi porno söyledim ve bende seni o anda sikeceğim ve sende kızını güzel giriyordum ablam çığlık atıyor ben de bi abandım arkadan ablam çok acıyor derken zevke geldi ataköy escort sırt üstü uzandım oda geldi ve bacaklarımı omzuna alıp içime girmeye başladı bayan escort sonra gögüs uçlarından öpmeye başladım ve daha aşağı kayıp şortunu indirerek muhteşem penisini emmeye başladım bir süre böyle devam ettik istanbul escort aşağı inerek bikinim üzerinden benim kadınlığımı uyarmaya başladı beni çıldırtıyordu ve bikinim kenara çekip dilini değdirdiğinde. takes up and uses glucose, for example, perhaps we could design a therapy to help the cones better utilize their glucose."

Researchers like Dr. Cepko are interested in cone survival, because even keeping a small fraction of these retinal cells alive and healthy can enable a person to see well enough to conduct most daily living activities without assistance.

In a second paper published in the journal Science (January 9, 2009), Dr. Cepko and colleague, Bo Chen, Ph.D., found that the protein HDAC4 prolonged the life of both healthy and diseased retinal cells. The sustaining effect of the protein is termed "neuroprotective."

While Dr. Cepko's study of HDAC4 was in mouse models of retinal degenerative disease, she believes the protein has strong potential to be effective in humans. She plans additional studies of HDAC4 to better understand its potential as a treatment in human retinal disease.

Stephen Rose, Ph.D., chief research officer, Foundation Fighting Blindness, notes that while translational research — moving potential treatments into the clinic — remains a priority, laboratory studies are also an important part of the Foundation's portfolio of research projects. "There is still much we need to understand about how the retina works," he says. "We need to understand the basic science to identify the best targets for treatments and cures."

Contributions from generous FFB donors across the country are making these kinds of breakthroughs possible.
 

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