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Graham Holder, Ph.D.
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Graham Holder runs the clinical electrophysiology service at Moorfields, Britain's best-known specialist NHS eye hospital. His department routinely examines more than 1,500 patients a year, many having multiple tests, including an electroretinogram. Dr Holder's research has established that even though some patients have mild symptoms, their electrophysiological abnormality is profound. Dr Holder's department has also extended the range of stimuli involved in ERGs, so that different populations of cells in the various layers of the retina are tested. The highly detailed information gathered in this way provides not just differential diagnosis but establishes the different ways in which genetically determined retinal disease makes itself apparent (the phenotype). Dr Holder and his colleagues have been responsible for characterising a wide range of genetic defects in this way. As progress is made towards treatment trials for these potentially blinding diseases, ERGs will not only identify suitable patients but also act as the outcome measure. |
