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• CNTF Time Table?
• Posted: 2007-08-07 15:24:24 By Michael Z
• All the news on CNTF seems very promising, especially with the feedback of the current patients in the trials. What is the realistic time on when this procedure will be made public to the people? Two years from today? Three years from today?
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• FFB Grant:Emory Eye Center
• Posted: 2007-08-07 14:53:24 By Darran Z
• This is interesting.
  
  http://www.dentalplans.com/articles/22619/
  
  Bear bile? Who would have known!
  
  Darran
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• Macular Hole Surgery
• Posted: 2007-08-06 14:20:06 By Reyne K
• I noticed that I had a blind spot in my central vision and didn't think it was the RP affecting my macula already. After having an OCT and an angiogram, a macular hole was confirmed. I will be off to the Wills Eye Center in Philadelphia for the vitrectomy surgery. Has anyone had this done? They don't want to combine the cataract surgery with this. I am really interested in the recovery afterwards.
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• ECT-CNTF QUESTION?
• Posted: 2007-08-06 09:38:18 By james n
• ECT-CNTF does this will stop the degeneration of the RETINITIS PIGMENTOSA?
  
  and how long the effectiveness of this CNTF?
  Do they run out?
  
  How do i know if my RP is late or early stage?
  
  My vision has tiny viens and arteries floating on on my eyesight, does CNTF can remove these? and what are these floating arteries and viens called?
  
  Thanks in advance.
  
  
  
  
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• Buying my first home
• Posted: 2007-08-05 23:17:58 By Mark B
• Are there any programs that assist disabled people with buying a home? I did a brief search, and didn't find anything useful.
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• FATHER FORGIVE ME.
• Posted: 2007-08-05 11:06:02 By james n
• Our father in heaven,
  Creator of heaven and earth
  My creator. FATHER..
  
  Please provide us now the cure for this RETINITIS PIGMENTOSA disease and all EYE DISEASES.
  
  Father forgive me... For who i am...
  And all my sins...
  If it is inevitable, father please accept me in heaven...
  
  
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• Drug Treatment for RP? Treatment of Damaged Retinas: New Drugs on the Horizon?
• Posted: 2007-08-04 21:57:34 By Darran Z
• This reminds me of Star Trek 4 when McCoy gives that lady a pill and she regenerates a kidney.
  
  Treatment of Damaged Retinas: New Drugs on the Horizon?
  
  
  Filed under: Ophthalmology
  Medgadget.com - San Francisco,CA,USA
  Friday, August 3, 2007
  
  
  Scientists from the RIKEN Research Institute and Kyoto University in Japan
  are reporting that when they stimulated a specific biochemical pathway they
  achieved retinal regeneration in a rat model:
  
  It is a discovery that may ultimately lead to new therapies for retinal
  diseases including the degenerative disease called retinitis pigmentosa.
  
  Previous research by the team led by Masayo Takahashi at the RIKEN Center
  for Developmental Biology, Kobe, demonstrated that retinal support cells
  called Muller glia could de-differentiate to assume a neuronal fate, but the
  level of regeneration via this mechanism was very low, occurring in just a
  few cells.
  
  But the new study, published recently in the Journal of Neuroscience,
  indicates that retinal cell regeneration in an in vitro model of retinal
  damage can be increased by as much as twenty-fold in the presence of the
  protein Wnt3a.
  
  The researchers initially performed experiments in cultured retinas isolated
  from rats. When they administered Wnt3a, they found a significant increase
  in proliferation of neuronal progenitors from the de-differentiated cells...
  
  "Newly generated cells constituted almost a layer of cells in the outer
  nuclear layer in the retinal degeneration model mice," says Takahashi. "We
  only observed several cells per field without Wnt treatment. Furthermore,
  the retinal neurons were regenerated all over the retina."
  
  The regenerated cells migrated to the outer nuclear layer of the retina,
  where, in the presence of retinoic acid (a form of vitamin A) or valproic
  acid, the team observed differentiation into rod photoreceptor cells.
  
  The phenomenon appears to involve the canonical Wnt signaling pathway, in
  which Wnt activation protects the â-catenin protein from degradation,
  allowing it to accumulate in the nucleus where it regulates gene
  transcription. The process could also be stimulated with small molecule
  inhibitors of glycogen synthase kinase-3â, which normally blocks activation
  of the pathway.
  
  Treatment of retinas isolated from a murine model of retinitis pigmentosa
  with Wnt3a similarly resulted in the regeneration of retinal cells,
  suggesting that the Wnt/â-catenin signaling pathway contributes to central
  nervous system regeneration.
  
  
  http://www.medgadget.com/archives/2007/08/treatment_of_damaged_retinas_new_drugs_on_the_horizon.html
  
  
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• ERG
• Posted: 2007-08-03 19:02:03 By Landy M
• Hi, I just received my authorization to have an ERG done. Can someone explain to me what the procedure is, needless to say I am a little nervous. Any info is appreciated.
  
  Thanks.
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• ERG
• Posted: 2007-08-03 18:54:46 By Landy M
• Hi, I just received authorization to get an ERG done, can anybody explain this procedure to me? Just a little nervous.
  
  Thanks.
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• May be one spot left for neurotech early study at Bascom
• Posted: 2007-08-03 18:09:30 By carolina s
• Hello
  I came back from my post- op follow up for the CNTF implant and the shared with me that from the 3 people recruited I was the only one to go though with it. The 2 people that had qualified, after all the intense testing etc. decided to back up right before schedulling surgery. The Dr was a bit upset about this, since she believes they took the spot from some other candidates that really wanted the surgery. SOOOOO.....there maybe one more last minute opening for the CNTF implant at Bascom Palmer.
  I can tell you that 3 days after my surgery I am doing SUPER !!!! very little discomfort and my Dr is very pleased with my outcome.
  cheers
  carolina
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• darran
• Posted: 2007-08-03 16:21:50 By julia b
• sorry!darran!
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• darren
• Posted: 2007-08-03 16:21:12 By julia b
• I stumbled across this,have you ever heard of this?
  http://www.worldmedics.com/vkagarwal/
  Julia
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• RP Center to Open In India
• Posted: 2007-08-03 15:24:00 By Suman K
• On April 12, 2007, Stem Cell Pharma Inc. (SCPI) USA and King Multitech Global Pvt LImited (KMT) India announced the signing of a Joint Venture (JV) by which a Retinitis Pigmentosa Center, a first of this type in the world, will open September of 2007 in Ludhiana, Punjab, India.
  This center would accommodate initially 10 patients a day, or up to 300 patients a month, at prices close to ones paid to SCPI; i.e. $8,000 per patient. India has a population of 400,000 patients with RP, a disease which had no treatment until now.
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• Test
• Posted: 2007-08-03 12:47:42 By Darran Z
• Testing...
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• Using Viagra
• Posted: 2007-08-03 11:33:36 By Michael D
• Is there any chance using viagra or other
  ED drugs is dangerous for people with RP?
  
  Thanks,
  Nike
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• MACULAR EDEMA
• Posted: 2007-08-02 18:30:55 By Nikki s
• so i went to a retianl specialist today and it turns out i have macular edema so they gave me two eye drops to take..anyone else have this?
  i was wondering why my vision was so blurry and no one else in my family has this ...so hopefully it will decrease the blurryness at least a little.
  
  Mr, D , do you know about this?
  thanx
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• STUDIES
• Posted: 2007-08-01 20:39:28 By AMY B
• ARE THERE ANY OTHER STUDIES GOING ON NOW?
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• MY AGE?
• Posted: 2007-08-01 20:38:38 By AMY B
• IS ANYONE HERE MY AGE?
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• Ages
• Posted: 2007-08-01 20:11:03 By Jacqueline B
• I posted a message for the first time the other day. My daughter is the 18 year old with RP. It is not in the family. HOw about anyone else? Darran how did you get so knowledgable about everything?
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• Zebrafish study may point way to blindness cure
• Posted: 2007-08-01 10:12:20 By Rose J
• A friend sent this article to me this morning. Just thought I'd share.
  
  http://news.yahoo.com/s/nm/20070801/hl_nm/blindness_fish_dc
  
  By Ben Hirschler
  Wed Aug 1, 2:25 AM ET
  
  
  LONDON (Reuters) - The ability of zebrafish to regenerate damaged retinas has given scientists a clue about restoring human vision and could lead to an experimental treatment for blindness within five years.
  
  ADVERTISEMENT
  
  British researchers said on Wednesday they had successfully grown in the laboratory a type of adult stem cell found in the eyes of both fish and mammals that develops into neurons in the retina.
  
  In future, these cells could be injected into the eye as a treatment for diseases such as macular degeneration, glaucoma and diabetes-related blindness, according to Astrid Limb of University College London's (UCL) Institute of Ophthalmology.
  
  Damage to the retina -- the part of the eye that sends messages to the brain -- is responsible for most cases of sight loss.
  
  "Our findings have enormous potential," Limb said. "It could help in all diseases where the neurons are damaged, which is basically nearly every disease of the eye."
  
  Limb and her colleagues studied so-called Mueller glial cells in the eyes of people aged from 18 months to 91 years and found they were able to develop them into all types of neurons found in the retina.
  
  They were also able to grow them easily in the lab, they reported in the journal Stem Cells.
  
  The cells have already been tested in rats with diseased retinas, where they successfully migrated into the retina and took on the characteristics of the surrounding neurons. Now the team is working on the same approach in humans.
  
  "We very much hope that we could do autologous transplants within five years," Limb told Reuters.
  
  Autologous transplants, initially on a trial basis, will involve manipulating cells and injecting them back into an individual's own eye. Eventually, Limb hopes it will also be possible to transfer the cells between different people.
  
  "Because they are so easy to grow, we could make stem cell banks and have cell lines available to the general population, subject to typing as with blood transfusions," she said.
  
  Just why zebrafish have an abundant supply of adult stem cells to regenerate their retinas, while they are rare in mammals, remains a mystery but Limb suspects it is because mammals have a limiting system to stop proliferation.
  
  The new work on Mueller glial cells is the latest example of researchers exploring the potential of different kinds of stem cells in treating eye disease. Another team from UCL and Moorfield's Eye Hospital said in June they aimed to repair damaged retinas with cells derived from embryonic stem cells.
  
  
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• HELP in Miami
• Posted: 2007-08-01 00:53:32 By odalys f
• my 11 year old brother was just diagnosed with RP... i just started doing research and there is so much info... does anyone recommend a specialist he can go to?
  
  odalys
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