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Nouvelle Lumière: French Bionic Retina in a Human Study

A rendering of Pixium's IRIS device.There’s no doubt that 2013 was a milestone year for bionic retinas. Previously approved for sale in Europe, Second Sight’s Argus II Retinal Prosthesis System received marketing approval in February from the U.S. Food and Drug Administration. Also, in July, Retina Implant AG gained European marketing approval for its Alpha IMS retinal implant.

While these two devices were in the media spotlight, a French retinal implant developer called Pixium quietly launched a clinical trial for its Intelligent Retinal Implant System 1 (IRIS1) in France, Austria and Germany. The company also recently received $20 million in venture-capital funding to boost advancement of the device.

A video on Pixium’s website provides a nice overview of the company and its IRIS technologies. To see it, click on the image below:

ISIS receiving an image and sending signals to the brain

In 2011, Pixium was spun off from the Institut de la Vision and Univeristé Pierre et Marie Curie. You might recognize the name of one of its co-founders, José Sahel, M.D. He’s funded by the Foundation for a number of highly promising research projects, including the development of optogenetic and vision-preserving gene therapies.

Pixium is also collaborating with the Commissariat à l’Energie Atomique (French Alternative Energies and Atomic Energy Commission), Hopital des Quinze Vingts (French National Eye Hospital) and a graduate school of engineering known as ESIEE Paris.

The IRIS1 consists of a small implant attached to the inner layer of the retina, a camera mounted on a pair of glasses and a pocket computer for image processing. The camera receives images that are processed, then sent to the implant, which converts them into electrical signals that are routed back to the brain, where they are interpreted as vision. The IRIS1 is designed to produce images of 150 pixels.

In future generations of the IRIS, advanced camera technology will capture and process images more like the human eye does. Likewise, the implant will produce higher-resolution visual information from those images, so the brain can create a more detailed and natural visual experience for the user.

The IRIS2 is being developed to produce 300-pixel images, and the IRIS3 5,000-pixel images, which Pixium researchers believe is more than enough for users to recognize faces and navigate new environments. Clinical trials for the IRIS2 and IRIS3 are expected to begin in 2014 and 2015, respectively.

Initial results for the IRIS1 human study are expected in 2014. Stay tuned to Eye on the Cure or FFB’s website for an update.

Images courtesy of Pixium.


4 Responses to 'Nouvelle Lumière: French Bionic Retina in a Human Study'

  1. THERESA BECKER says:

    2 SONS WITH RP

  2. Jenny rollins says:

    I have suffered with vision problems all my life and have recently gone blind I have uveitis as a result of juvenile rheumatoid arthritis I am obviously always interested in anything that can help me so please if there is let me know

    • Eye on the Cure says:

      Hi Jenny,

      Thank you for your message. Unfortunately, we can only speak about research for retinal degenerative diseases that affect the retina in the eye. Your doctors and other eye specialists will be best suited to answer your questions about what treatments are available for your own condition.

      You may want to visit the website of the National Eye Institute (http://www.nei.nih.gov/) or reach out to someone at the institute – they may be able to point you in the correct direction on other resources or organizations who specialize in your condition.

      We wish you all the best as you try to find out more.

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